BRMEC12 Colloquium 2022

The 12th International Biomedical Research into ME Research Colloquium took place on 31 May - 1 June 2023.
Developing further insights into mechanisms and complexity of myalgic encephalomyelitis including aspects of long covid research.

ME and Long Covid: Emerging insights in mechanisms and complexity of post-viral fatigue


ME, and more recently Long Covid, place a huge burden in healthcare yet the capacity of research has continually been restricted by limited funding.
With developments around research into Long Covid and with the similarities of some symptoms to those experienced by people with ME then this topic was also included as a central component of the agenda and a number of presentations concerning ME and long covid were given with a focus on the aetiology of the disease.
The knowledge and the road travelled by ME researchers and clinicians is an invaluable aid for understanding long Covid.
Understanding the viral and immunological mechanisms behind both of those conditions is the key to making progress.

The 12th Biomedical Research into ME Colloquium was possibly the best yet of the series of colloquia that were started in 2011, five years after we initiated the international ME conferences.
This year Invest in ME Research started late in preparations, unsure of the response from researchers following easing of covid restrictions. However, the team managed to bring together a good programme of interesting research and used the expertise of the European ME Research Group (EMERG) to chair sessions and bring in new expertise alongside the existing and increasing family of researchers that the charity has developed.
There was more interest from researchers than ever - despite this being our first to meet in person since before the pandemic began - justifying resources used/commitment given to make it work.
This year also, partly as an aid to help social distancing at the events, we used a new venue which had the added benefit of giving greater possibilities to improve and develop international collaboration amongst researchers, one of the charity's continuing and abiding objectives.
In this we feel we were very successful.
Many new collaborations were formed - one of the advantages of focusing efforts on getting the right people together in a productive atmosphere.
Many of these collaborations may not come to fruition for a while but they were, nevertheless, generated by the ability to meet in pleasant surroundings and inspired with the atmosphere of this international meeting. As one good friend and BRMEC12 delegate commented -
‘the agenda, speakers you chose, networking you encouraged & every detail helped us all meet new collaborators & have more hope that things are getting closer to answers’
Amongst some of the invitations to attend from the charity there was included one to the Norwegian Directorate of Health (Norges Helsedirektoratet). The situation for ME in Norway should be the best in the world but there are continuing issues with flawed policies being promoted.
So, we suggested to one of the EMERG researchers in Norway if we could assist by inviting such an organisation to the Colloquium as our guests to hear of the research that was being conducted and to mix with researchers.
Eventually we had four representatives from helsedirektoratet attending and we hope that this will prove beneficial to all people with ME and their carers in Norway, and ultimately to all patients in Europe.


# Session Presenter(s)
Welcome and Introduction Simon Carding
Quadram Institute, UK / European ME Research Group (EMERG)
Modelling Session Chair: Jonas Bergquist, University of Uppsala, Sweden
Pathophysiological Basis of Fibromyalgia David Andersson
Kings College London, UK
Development of a Novel Mouse Model for ME/CFS Gunnar Gottschalk
Simmaron Research, USA
Discussions Chaired discussion amongst delegates
Immunology and Autoimmunity Session Chair: Amolak Bansal, UK / EMERG
Immunogenetic studies of ME/CFS Marte Viken
University of Oslo, Norway / EMERG
tbc Lutz Schomburg
Charité University Hospital, Germany / EMERG
- Discussions Chaired discussion amongst delegates
Host Virus Interaction - ME and Long Covid Session Chair: Tom Wileman
Quadram Institute, UK / EMERG
Coming Full Circle: Rethinking the Role of Virus in ME/CFS and the Implications for Long COVID Nancy Klimas
Nova Southeastern University, USA
ME/CFS and Long COVID: NIH STUDY Avindra Nath
National Institues of Health (NIH), USA
Post-covid ME and Comparative Studies (tbc) Jonas Bergquist
University of Uppsala, Sweden / EMERG
Long Covid to ME/CFS Transition (tbc) Alain Moreau
Université de Montréal, Canada
- Discussions Chaired discussion amongst delegates
Herpesvirus reactivation as a trigger for ME/CFS (tbc) Bhupesh Prusty
University of Würzburg, Germany
Neurological infection and Development of Models (tbc) James Stewart
University of Liverpool, UK
Discussions Chaired discussion amongst delegates
- Microbiome Session Chair: Simon Carding
Quadram Institute, UK / EMERG
Multi-'omics of host-microbiome interactions in short- and long-term ME/CFS (tbc) Julia Oh
Jackson Laboratory, USA
Deficient butyrate-producing capacity in the gut microbiome is associated with bacterial network disturbances and fatigue symptoms in ME/CFS (tbc) Brent Williams
Columbia University, USA
Antibody responses against human microbiota flagellins in ME/CFS (tbc) Thomas Vogl, Medical University of Vienna, Austria
Gut complications in autonomic dysfunction associated with Postural Tachycardia Syndrome Qasim Aziz, Queen Mary University London, UK
Discussions Chaired discussion amongst delegates
- Summary Day 1 Discussions Chaired discussion amongst delegates

# Session Presenter(s)
09:00 Welcome and Overview of Day 2 Simon Carding
Quadram Institute, UK / European ME Research Group (EMERG)
- Mitochondrial Dysfunction and Metabolomics Session chair: Rikke Olsen
Aarhus Universitet, Denmark / EMERG
ME/CFS and Long COVID:
Insights from Invasive Cardiopulmonary Exercise Testing
David Systrom
Harvard Medical School, USA
Metabolic Modeling in ME/CFS and COVID Wenzhong Xiao
Harvard Medical School, USA
Metabolic profiling and associations to clinical data in ME Karl Johan Tronstad
University of Bergen, Norway / EMERG
Plasma Proteomics in ME Maureen Hanson
Cornell University, USA
Sex-dependent Transcriptional Changes in Patients with ME/CFS in Response to Exercise – pilot study Lubov Nathanson
Nova Southeastern University, USA
Mitochondrial myopathies in long COVID Hatice Tankisi
Aarhus University, Denmark
- Discussions Chaired discussion amongst delegates
- Imaging Session chair: Professor Angela Vincent, University of Oxford, UK
- Neurological and Ion Channel Disturbances in ME/CFS and Long COVID Kiran Thapaliya
NCNED, Australia
- Discussions Chaired discussion amongst delegates
- Network and Systems Biology Approaches for ME Session chair: Professor Elisa Oltra, Universidad Catolica de Valencia San Vicente Mártir, Spain
AI and Stratification of Patients into Subgroups Based on Genetic Profile Tamas Korcsmaros
Imperial College London, UK
The interferon-alpha-itaconate shunt hypothesis for the pathogenesis of ME Robert Phair
Integrative Bioinformatics Inc, USA
tbc Ron Davis
Stanford Genome, USA
Discussions Chaired discussion amongst delegates
- Therapies and Treatments Session chair: Dr Jesper Mehlsen
Copenhagen University Hospital, Denmark / EMERG
Differences in the clinical picture of ME/CFS and Long Covid Markku Partinen, University of Helsinki, Finland
Research on severely ill ME patients Professor Ola Didrik Saugstad / Dr Dag Storla
University of Oslo, Norway / EMERG
Toward uniform treatment regimen for ME/CFS Dr Jesper Mehlsen
Copenhagen University Hospital, Denmark / EMERG
Using Red Light Therapy to Enhance Mitochondrial Function in People with ME Glen Jeffery
UCL, UK
Development of a therapeutic compound for ME/CFS and Long Haul COVID Bradlee Heckmann
University of South Florida, USA
- Discussions Chaired discussion amongst delegates
- BRMEC12: Summary and Group Discussion - Next Steps Chaired discussion amongst delegates


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Last updated: December 2025