Invest in ME Research Biomedical Research Colloquiums

The Invest in ME Research Biomedical Research into ME (BRMEC) Colloquiums are research meetings organised by the charity to encourage biomedical research into ME and international collaboration amongst researchers.
This has been one of the main objectives of the charity.


Invest in ME Research began arranging biomedical research conferences in our first year and have continued them ever since - mostly funded by the charity but with help from some wonderful supporters and some good friends.

The Invest in ME Research International Biomedical Research into ME Colloquiums began in 2011 as a way of bringing together researchers from around the world in a round-table discussion of ME research and ideas.
Over the years this has broadened into sharing of experiences, data and plans for future research and international collaboration.
A culmination of much of this effort was the initiation of The European ME Research Group (EMERG) concept which formed in October 2015 in London in an attempt to set up a strategy of European collaboration in ME research.

We are building a basis for creating a strategy of high-quality international biomedical research - something which has been lacking in the past decades.
This will hold great promise of finding funding opportunities and raising awareness of biomedical research into ME.

Our aim with the annual CPD-accredited research colloquiums has also been to introduce new researchers into the field of ME research, to gain new insights into the disease and enhance the strategy of research we are building.

In 2020 we continue developing foundations for the future by arranging another Thinking the Future workshop for the network of young and early career researchers interested in or already performing biomedical research into ME.

The Invest in ME Research Colloquiums have spawned a number of positive initiatives over the years and are the most successful research meetings for forming new research initiatives for ME with multiple collaborative initiatives being formed across continents.


Latest Colloquium BRMEC10


BRMEC10 is the latest Colloquium planned for May 2020. Visit the distinct page for that Colloquium
Click here


Biomedical Research into ME Colloquium 9 - 29th - 30th May 2019

BRMEC8


IIMER BRMEC9 Research Meeting London, 2018

29 - 30 May 2019

The Invest in ME Research Biomedical Research into ME Colloquium 9 (BRMEC9) took place in London over two days and was the ninth Colloquium arranged by the charity.

We had representation from National Institutes of Health (NIH), Centers for Disease Control (CDC), USA, Canada, Europe and Australasia

BRMEC9 AGENDA

Click below to expand and show each day of the Colloquium
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Biomedical Research into ME Colloquium 8 - 30th - 31st May 2018

BRMEC8


IIMER BRMEC8 Research Meeting London, 2018

30 - 31st May 2018

The Invest in ME Research Biomedical Research into ME Colloquium 8 (BRMEC8) will take place in London over two days from 30th - 31st May 2018.

The eighth Colloquium aims to increase international collaboration in research into ME.

We have representation from most of the main biomedical research initiatives now occurring throughout the world and also participation fron USA's Centers for Disease Control (CDC) and National Institutes of Health (NIH).

The research Colloquium in London will precede the IIMEC13 annual public international biomedical research conference on 1st June 2018.

BRMEC8 AGENDA

Click below to expand and show each day of the Colloquium
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The schedule is subject to change

#BRMEC8 Day 1 is followed by a researchers' dinner organised by IiMER where more discussions are able to be carried out between researchers.

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The schedule is subject to change

#BRMEC8 Day 2 is followed by the #IIMEC13 International ME Conference 2018 Pre-Conference Dinner


Biomedical Research into ME Colloquium 7 - 31st May - 1st June 2017

BRMEC7


IIMER BRMEC7 Research Meeting London, 2017

31st May - 1st June 2017

The Biomedical Research into ME Colloquium 7 (BRMEC7) took place in London over two days from 31st - 1nd June 2017.

This was the seventh Invest in ME Research Colloquium and the objective was to increase international collaboration in research into ME.

Chairing and participating in the meeting were members of the Invest in ME Research Advisory Board and the newly formed European ME Research Group (EMERG).

We had representation from most of the main biomedical research initiatives occurring throughout the world as well asparticipation from the USA by the CDC and NIH.

The research Colloquium in London preceded the IIMEC12 international biomedical research conference on 2nd June 2017.

BRMEC7 AGENDA

Click below to expand and show each day of the Colloquium
BRMEC7 - Day 1
Welcome to the 7th Invest in ME Research International Biomedical Research into ME Colloquium 7 2017 Dr Ian Gibson, UEA, UK
NIH Research into ME - Status Update and Plans Dr Vicky Whittemore, NIH, USA
CDC Multisite study and future plans Dr. Elizabeth Unger, CDC, USA
Data Collection (including the following)
Modelling Professor Nancy Klimas, Fort Lauderdale, USA
Long-term follow up: Experience and lessons for ME from Norfolk Arthritis Registry Project (NOAR) Professor Alex MacGregor, Norwich, UK
Discussion
Immunology (including the following)
Dysregulation of Transient Receptor Potential (TRP) ion channels and calcium in natural killer cells in CFS/ME patients’ Professor Sonya Marshall-Gradisnik, NCNED, Australia
Professor Don Staines, NCNED, Australia
Update on B-cell research and future plans at UCL Dr Jo Cambridge, London, UK
Fane Mensah, London, UK
Studies of NK cells and cytotoxic T-cells in ME-patients from one Swedish and one Norwegian cohort Dr Jakob Theorell, Stockholm, Sweden
EBV and lymphoma Professor Michelle West, Sussex, UK
Discussion
Metabolomics (including the following)
Stanford Update Professor Ron Davis, Stanford Genome Institute, USA
Cornell Update Professor Maureen Hanson, New York, USA
Australian Update Dr Chris Armstrong, Melbourne, Australia
Overview of metabolism studies at Haukeland Professor Karl Johan Tronstad, Bergen, Norway
Discussion
Neuroimaging (including the following)
ME imaging review and ongoing study Dr Per Julin, Stockholm, Sweden
Discussion

BRMEC7 - Day 2
Opening 7th Invest in ME Research International Biomedical Research into ME Colloquium 7 2017 - Day 2 Dr Ian Gibson, UEA, UK
Clinical Trials (including the following)
LDN in ME/CFS: data on safety and efficacy Dr Olli Polo, Tampere, Finland
RituxME and CycloME clinical trials Professor Olav Mella, Bergen, Norway
Impaired glucose metabolism and PDH in ME/CFS? Dr. Øystein Fluge, Bergen, Norway
B-vitamins in ME/CFS Dr. Ingrid G. Rekeland, Bergen, Norway
Immunadsorbtion trial Professor Carmen Scheibenbogen, Berlin, Germany
Discussion
Microbiome (including the following)
IFR/UEA update Professor Simon Carding, Norwich, UK
Alterations in the enteric bacterial and viral microbiome in ME/CFS Professor Ludovic Giloteaux, New York, USA
Columbia update Associate Professor Mady Hornig, New York, USA
Discussion
Biomarkers (including the following)
miRNA in CSF Professor James Baraniuk, Washington DC, USA
Epigenetic changes in ME/CFS Dr Lubov Nathanson, Fort Lauderdale, USA
Genetic and functional genetic studies in ME / HLA and ME Dr Asgeir Lande , Oslo, Norway
Professor Ola Didrik Saugstad , Oslo, Norway
Tbc Professor Warren Tate, Otago, New Zealand
Lactate during exercise in ME/CFS Dr Katarina Lien, Oslo, Norway
Discussion
Colloquium Summary

Biomedical Research into ME Colloquium 6 - 1st - 2nd June 2016

BRMEC6


IIMER BRMEC6 Research Meeting London, 2016

1st - 2nd June 2016

The CPD-accredited Biomedical Research into ME Colloquium 6 (BRMEC6) took place in London over two days from 1st - 2nd June 2016.

This was the sixth Invest in ME - Research Colloquium and the objective was to increase international collaboration in research into ME.

The sixth colloquium was opened by Dr Vicky Whittemore of the USA National Institute of Research.

With full CPD accreditation the Colloquium involved the most experienced researchers in areas such as immunology, virology, neurology and bioinformatics.

Chairing and participating in the meeting were members of the Invest in ME Research Advisory Board and the newly formed European ME Research Group (EMERG).

We again had most of the main biomedical research initiatives now occurring throughout the world represented at the meeting.

The research Colloquium was in London and preceded the IIMEC11 annual international biomedical research conference on 1st June 2016.



BRMEC6 AGENDA

Click below to expand and show each day of the Colloquium
BRMEC6 - Day 1
Welcome to the 6th Invest in ME International Biomedical Research into ME Colloquium Dr Ian Gibson, UEA, UK Professor Jonathan Edwards, UCL, UK
NIH Research into ME Dr Vicky Whittemore, NIH, USA
Diagnosis (clinical) – Patient Stratification (including the following)
Clinical signs/symptoms of ME Professor Olli Polo, Tampere University, Finland
Diagnostics and Patient Stratification for Research Dr Amolak Bansal, Epsom & St Helier NHS Trust, UK
Protocols and Patient Databases for ME Dr Luis Nacul, LSHTM, UK
Big Data Approach: Severely Ill ME Cohort Professor Ron Davis, Stanford, USA
Chaired Discussion - Criteria to Use for ME/CFS Diagnosis Professor Angela Vincent, Oxford University, UK
Sample Standardisation SOPs for Research (including the following)
Biobank Samples and Protocols for UK/Europe Dr Eliana Lacerda, LSHTM, UK
Analysis Protocols for ME Professor Jonas Bergquist, Uppsala University, Sweden
Chaired discussion Sample Standardisation SOPs for Research Dr Jo Cambridge, UCL, UK
Biomarkers: 1 Data
Keynote Speech: Longitudinal Immunological & Virological Study for ME/CFS Biomarker Discovery Professor Eleanor Riley, LSHTM, UK
Biomarkers: 2 Imaging
Immune-Brain Communication and Relationship to Inflammation and Cohort Selection Challenges Dr Neil Harrison, Sussex University, UK
Neuroimaging in Clinical Practice in ME tbc
Chaired Discussion Neuroimaging in ME Research Professor Jonathan Edwards, UCL, UK
Biomarkers: 3 Mitochondria
Keynote Speech: Understanding and Preventing Mitochondrial Oxidative Damage Dr Mike Murphy, MRC and Cambridge University, UK
Mitochondria in ME/CFS Professor Maureen Hanson, Cornell University, USA
Chaired discussion/workshop with participants Professor Jonas Blomberg, Uppsala University, Sweden
Adjourn

BRMEC6 - Day 2
Summary Day 1 - Objectives of DAY 2 Dr Ian Gibson, UEA, UK Professor Jonathan Edwards, UCL, UK
Biomarkers: 4 Antibodies (including the following)
Autoantibodies in ME/CFS Professor Carmen Scheibenbogen, Charite, Berlin, Germany
Antibodies to small DNA viruses Professor Jonas Blomberg, Uppala Uuniversity, Sweden
Novel form of RNaseL Professor Elisa Oltra, Cell and Molecular Biology at the Universidad Católica de Valencia “San Vicente Mártir”,  Spain
B cell biology and ME Dr Jo Cambridge, UCL, UK Fane Mensah, UCL, UK
Chaired discussion Antibodies in ME/CFS Dr Juliá Blanco, IrsiCaixa, Institute for AIDS Research, Spai
Biomarkers: 5 Big Data Updates
Big Data Approach for ME/CFS at Columbia University Professor Mady Hornig, Columbia University, USA
Big Data Update from Stanford Professor Ron Davis, Standord Genome, USA
Recent discoveries from NCNED data set: Gene expression & Receptor id Dr Don Staines, NCNED, Australia
Chaired discussion - Challenges of Big Data Strategies Professor Jonas Bergquist, Uppsala University, Sweden
Biomarkers: 6 Phenotypes (including the following)
Glucocorticoid Resistance in ME Dr Amolak Bansal, Epsom & St. Helier NHS, UK
Exercise Data, Orthostatic Tachycardia and Proteomics in ME Professor James Baraniuk, Georgetown University, USA
Virome and Gut Microbiota in ME Professor Tom Wileman, UEA, UK
Gut Microbe and Metabolomic Study of ME/CFS Patients Dr Christopher Armstrong, Dept Biochemistry and Molecular Biology, University of Melbourne, Australia
Discussion: Phenotypes in ME/CFS Professor Simon Carding, UEA/IFR, UK
Systems Biology (including the following)
A Systems Biology approach Dr Travis Craddock, Nova Southeastern University, Miami, USA
Novel Treatments (including the following)
Novel Treatments - Immunoadsorption Professor Carmen Scheibenbogen, Charite Berlin, Germany
Medical Education - BMJ Update Professor James Baraniuk, Georgetown University, USA
SUMMARY of BRMEC6 - Objectives Status Dr Ian Gibson Professor Jonathan Edwards
Adjourn

Biomedical Research into ME Colloquium 5 - 27-28th May 2015

BRMEC5


BRMEC5 IiME Research Meeting London, 2015

The Biomedical Research into ME Colloquium 5 (BRMEC5) took place over two days from 27th-28th May 2015.

This was the fifth Invest in ME Research Colloquium and over sixty researchers from thirteen countries round the world convened in London to discuss research, strategies and future planning.

The fifth colloquium built on past years and has now evolved into a major international event, with CPD accreditation, and involving the most experienced researchers in areas such as immunology, virology, neurology and bioinformatics.

Chairing the meeting was Dr Ian Gibson and Professor Jonathan Edwards - along with the Invest in ME Research Advisory Board.

The research meeting was by invitation only but the charity made available places for researchers and some students who would add to the meeting or who were interested collaborating with our increasing group of international researchers in performing biomedical research into ME.

We had representatives from most of the main biomedical research initiatives now occurring throughout the world represented at the meeting.

BRMEC5 - Day 1
Welcome to the 5th Invest in ME International Biomedical Research into ME Colloquium Dr Ian Gibson/ Professor Jonathan Edwards
Foundations for Research
Epidemiology: Incidence/Prevalence in UK Dr Luis Nacul, London School of Hygiene and Tropical Medicine, UK
Diagnostics/patient selection for research -
Experience from clinic/Characteristics of patients – from new to severely ill
Dr Amolak Bansal, Epson and St.Helier NHS University Hospital, UK
IOM Implications Dr Dan Peterson, Simmaron Research, USA
Discussions
Chaired discussion with participants
Immunology 1: Gut Microbiota - Session Lead Professor Simon Carding (IFR)
USA Columbia Microbiome study Prof Mady Hornig, Columbia Univ, USA
The Cornell Microbiome Study Prof Maureen Hanson Cornell Uni,USA
Discussions
Chaired discussion with participants
Immunology 2:
Immunological and metabolic markers Prof Mady Hornig Columbia Univ, USA
B cell biology Dr Jo Cambridge UCL, UK
Immunological markers in a Spanish patient cohort Dr Julian Blanco, Irsi Caixa, Spain
Lymphocyte markers of fatigue in CFS/ME & breast cancer patients Dr Clive Carter, Leeds Teaching Hospitals NHS Trust, UK
Cytokine and Chemokine Profiles of ME/CFS Patients Dr Amir Landi, University of Alberta, Canada
Discussions
Chaired discussion with participants
Virology
Enteroviral Research into ME/CFS Dr John Chia, UCLA, USA
EBV and ME/CFS Prof Carmen Scheibenbogen Charite, Berlin, DE
Discussions Chaired discussion with participants
Summary of first day Dr Ian Gibson, UEA, UK
Prof Jonathan Edwards, UCL, UK
Adjourn

BRMEC5 - Day 2
Welcome - Overview/summary of previous day Objectives of DAY 2 Dr Ian Gibson, UEA, UK Prof Jonathan Edwards, UCL, UK
Neurology: Lead Angela Vincent (Oxford Univ.)
Keynote Speech:
Imaging Inflammation and Its Role in Neurodegeneration
Professor David Brooks, Imperial College London, UK
Immune-Brain Communication and Relationship to Inflammation Dr Neil Harrison Sussex Uni, UK
FMRI and ME/CFS Prof James Baraniuk Georgetown University, USA
Discussions
Chaired discussion with participants
Biomarkers
Immunological markers in ME/CFS Professor Sonya Marshall-Gradisnik
Professor Don Staines Griffiths University, Australia Australia
Vision and ME/CFS Dr Claire Hutchinson Leicester Uni., UK
CSF Proteomics in a Swedish ME/CFS patient cohort Prof Jonas Bergquist Uppsala Uni, Sweden Sweden
Glucocorticoid receptors and ME/CFS Dr Amolak Bansal, Epsom and St Helier NHS University Hospital, Surrey, UK
Molecular markers before/after exercise Prof Betsy Keller, Cornell Uni, USA
Discussions
Chaired discussion with participants
Clinical trials
Trial design, good practice Prof Jonathan Edwards, UCL, UK
Norwegian rituximab research/trials Prof Olav Mella/ Dr Oystein Fluge Haukeland Uni.,Norway
Discussions
Chaired discussion with participants
Additional Topics
Funding tbc
Discussions
Chaired discussion with participants
Adjourn


Biomedical Research into ME Colloquium 4 - 30th May 2014

BRMEC4

BRMEC4 Research Meeting London, 2014

The BRMEC4 Colloquium was intended to harness the potential of international collaboration with an objective of extending research cooperation and help drive new initiatives with biomedical research into ME.

The research meeting was in London and preceded the IIMEC9 annual international biomedical research conference on 30th May 2014.

Almost 50 researchers from nine countries attended the colloquium and a number of new initiatives were created which will benefit biomedical research into ME.

Welcome to London and BRMEC4 2014

Dear Participants,

Welcome to the Invest in ME Biomedical Research for ME Colloquium Meeting (BRMEC4) on 29th May 2014. Thank you again for participating in this exciting and innovative meeting which builds on the foundations made in previous years through meetings organised by the dedication and commitment of Invest in ME and its supporters.

Promising developments have been initiated in recent years which have created important possibilities for changing the way that Myalgic Encephalomyelitis (ME, known also as or ME/CFS or Chronic Fatigue Syndrome (CFS)) is researched and the way that patients are treated. High-quality research by an impressive group of researchers and physicians, with an emphasis on international collaboration - these are the aims of Invest in ME and it is our intention to continue to facilitate this and encourage new scientific research endeavours to understand the pathogenesis of ME.

This will be our fourth international ME research colloquium in London, taking place prior to our annual IiME international conference, and we look forward to enabling a unique contribution to understanding ME and suggest future research. For those who can use CPD points then this meeting has been awarded 6 CPD points by the Royal Colleges.

Co-Chairs of the meeting will be Dr Ian Gibson, former Dean of Biology at UEA, and Emeritus Professor of Connective Tissue Medicine Jonathan Edwards, University College London.

We look forward to meeting up in London.

Warm regards

Kathleen McCall Chairman Invest in ME

Invest in ME BRMEC4
Welcome and introductions Co-Chairs: Dr. Ian Gibson Prof.Jonathan Edwards UCL
Pathogen Discovery and Pathogenesis - CFI Dr. Mady Hornig, Columbia Univ, USA
Infection-induced autoimmunity in ME Prof. Jonas Blomberg, Uppsala Univ, Sweden
Microbiome of ME/CFS patients Prof. Maureen Hanson, Cornell Univ.,USA
OMI research Update Dr Andreas Kogelnik, OMI, USA
Chaired Discussions Prof. Jonathan Edwards/Dr.Ian Gibson
Antibodies in Neurological Diseases Prof. Angela Vincent, Oxford Univ.
Rituximab multi-centre clinical trial Prof.Olav Mella/Dr. Oystein Fluge, Bergen, Norway
Rituximab UK clinical
- Preliminary B-cell study
Dr. Jo Cambridge, UCL, UK
EBV and ME Prof. Carmen Scheibenbogen, Charite, Berlin
Chaired Discussions Prof. Jonathan Edwards/Dr.Ian Gibson
Update on ANS studies Prof. Julia Newton, Newcastle, UK
Brain imaging and ME Prof. James Baraniuk Georgetown Univ., USA
NK-, B- and T-cell phenotypes and function in patients suffering from ME Prof. Sonya Marshall-Gradisnik, Griifiths Univ.,Australia
ME Biobank Dr. Eliana Lacerda/Dr Luis Nacul, LSHTM
Chaired Discussions Prof. Jonathan Edwards/Dr.Ian Gibson
Ways to Continue Collaboration and Discovery Funding Possibilities - IiME Proposal Plenary: Prof. Jonathan Edwards/Dr.Ian Gibson
Closing Summary and Future Directions Prof. Jonathan Edwards/Dr.Ian Gibson Briefing to Invest in ME Conference

A report of BRMEC4/IIMEC9

Biomedical Research into ME Colloquium 3 - 2013

BRMEC3

BRMEC3 Research Meeting London, 2013

In May 2013 the Biomedical Research into ME Collaborative meeting was held in London with 40 researchers from 9 countries attending, prior to the IIMEC8 Invest in ME International ME Conference 2013 - http://bit.ly/ZK7eoC To raise awareness of ME, and promote collaboration, innovation and foundations for a clearer strategy of biomedical research into ME, Invest in ME and the Alison Hunter Memorial Foundation of Australia continue the collaboration which has been a feature for several years, and which established the Clinical Autoimmunity Working Group which met in London in May 2012.

To achieve continued progress in understanding and treating this disease we must establish collaborations between biomedical researchers who can agree a clear strategy of biomedical research. Therefore, to attempt to increase collaboration and awareness and to encourage new researchers to the field we are arranging a research meeting which brings together major researchers in order to crowd source ideas on ME research - a Biomedical Research into ME Collaborative meeting. Representatives from seven countries attended.

Since its inception Invest in ME have campaigned for biomedical research into ME. IiME began arranging our biomedical research conferences in our first year and have continued them ever since - mostly funded by the charity but with help from some wonderful supporters and some good friends.

At our IIMEC8 conference we focus on ME now becoming a mainstream research area. We have representatives from most of the main biomedical research initiatives now occurring throughout the world.

Welcome to London and BRMEC3 2013

Dear Friends,

It is an honour to welcome you to London and the Biomedical Research into ME Collaborative meeting. This meeting has been made possible through the continued commitment to biomedical research being made by UK charity Invest in ME and their supporters.

The objectives of the meeting are:

1. To present the status of the latest initiatives occurring in biomedical research into ME

2. To discuss and explore the possibilities for collaboration and for funding for biomedical research into ME

3. To generate new ideas regarding research into ME and assess research strategies for ME research

4. Review evidence for immunological derangement in ME

5. Review experiences and expertise from other research areas in order to assist ME research

6. To discuss opportunities for extending clinical trials in multiple centres and possibly internationally

7. To plan future events

We hope that the meeting will initiate new collaborations and generate new ideas for biomedical research into ME and help researchers support each other in the future.

The extraordinary skill and experience which can be harnessed by meetings such as last year’s Clinical Autoimmunity Working Group meeting in London and this year’s BRMEC meeting, as well as the possibilities to progress further understanding of the disease by “crowdsourcing” experience and ideas, promises to enable a unique contribution to understanding ME and suggest future research directions and perhaps treatments.

Chairing the meeting will be Dr Ian Gibson, former Dean of Biology at UEA and Professor Hugh Perry of Southampton University Chair of the Medical Research Council Neurosciences and Mental Health Board.

Invest in ME is keen and willing to support further collaborative efforts in biomedical research into ME and welcome the opportunity to continue these joint efforts,

Warm regards

Kathleen McCall Chairman Invest in ME

Invest in ME Research BRMEC3
Welcome and introductions (Chairs: Dr Ian Gibson/Professor Hugh Perry)
Pathogen Discovery and Pathogenesis = CFI (Professor Mady Hornig)
Retroviruses and ME (Professor Greg Towers)
Pathogen Discovery (Professor Jonas Blomberg)
Gut Microbiota and ME (Professor Simon Carding)
Chaired Discussions (Dr Ian Gibson/Professor Hugh Perry)
Experience of Rituximab in ME/CFS and present a case for extending clinical trials
as per Norwegian protocols or other parallel trials
(Dr Oystein Fluge/ Professor Olav Mella)
Rituximab in autoimmune diseases (Dr Jo Cambridge)
Update on immunological derangement that may dovetail with the Fluge et al findings. (Dr Don Staines)
Screening NK-, B- and T-cell phenotype and function in patients suffering from ME (Dr Julià Blanco)
Chaired Discussions (Dr Ian Gibson/Professor Hugh Perry)
ANS studies (Professor Julia Newton)
FDA Meeting outcome /Treatment with Vistide (Dr Dan Peterson)
OMI MERIT Strategy (Dr Andy Kogelnik)
Chaired Discussions (Dr Ian Gibson/Professor Hugh Perry)
Funding Possibilities
Ways to Continue Collaboration and Discovery
Chaired Discussions (Dr Ian Gibson/Professor Hugh Perry)
Closing Summary and future directions (Ian Gibson/Hugh Perry/IIME)